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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Radiation-induced osteosarcoma and papillary carcinoma of the thyroid
Adam Tonakie1, Barry L Shulkin, James C Sisson
1Department of South Coast Radiology, Mermaid Beach, Australia. barry.shulkin@stjude.org
Purpose:
This article describes a patient with dual radiation-induced malignancies after treatment of neuroblastoma.
Materials And Methods:
A 12-year-old boy with a history of neuroblastoma was treated with chemotherapy, I-131 MIBG, and radiotherapy at age 4. He was disease-free for 8 years, but then developed left shoulder pain resulting from osteosarcoma. A thyroid malignancy was discovered during the evaluation.
Results:
The patient was treated with thyroidectomy and then chemotherapy according to a Children's Cancer Group Study protocol.
Conclusion:
Radiation-induced sarcoma should be suspected whenever a patient who has received radiation several years previously presents with pain or swelling in the irradiated area.
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