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Updated: Aug 14, 2026
Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
Published on: February 8, 2018
Imaging polarimetry in central serous chorioretinopathy
Masahiro Miura1, Ann E Elsner, Anke Weber
1Department of Ophthalmology, Tokyo Medical University, Kasumigaura Hospital, 3-20-1 Chuo, Ami, Inashiki, Ibaraki 300-0395, Tokyo, Japan. m-miura@tokyo-med.ac.jp
Purpose:
To evaluate a noninvasive technique to detect the leakage point of central serous chorioretinopathy (CSR), using a polarimetry method.
Design:
Prospective cohort study.
Setting:
Institutional practice.
Patients:
We examined 30 eyes of 30 patients with CSR.
Main Outcome Measures:
Polarimetry images were recorded using the GDx-N (Laser Diagnostic Technologies). We computed four images that differed in their polarization content: a depolarized light image, an average reflectance image, a parallel polarized light image, and a birefringence image. Each polarimetry image was compared with abnormalities seen on fluorescein angiography.
Results:
In all eyes, leakage area could be clearly visualized as a bright area in the depolarized light images. Michelson contrasts for the leakage areas were 0.58 +/- 0.28 in the depolarized light images, 0.17 +/- 0.11 in the average reflectance images, 0.09 +/- 0.09 in the parallel polarized light images, and 0.11 +/- 0.21 in the birefringence images from the same raw data. Michelson contrasts in depolarized light images were significantly higher than for the other three images (P < .0001, for all tests, paired t test). The fluid accumulated in the retina was well-visualized in the average and parallel polarized light images.
Conclusions:
Polarization-sensitive imaging could readily localize the leakage point and area of fluid in CSR. This may assist with the rapid, noninvasive assessment of CSR.