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Antiplatelet agents and arterial thrombosis

Henny H Billett1

  • 1Albert Einstein College of Medicine, Thrombosis Prevention and Treatment Program, Department of Medicine, Division of Hematology, Montefiore Medical Center, Bronx, NY 10467, USA. hbillett@montefiore.org

Clinics in Geriatric Medicine
|December 27, 2005
PubMed

Insights

Elderly individuals face higher arterial thrombotic event risks due to age and comorbidities. This review examines antiplatelet therapies like aspirin and clopidogrel in older adults, highlighting underuse despite potential benefits.

Area of Science:

  • Geriatric Medicine
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Arterial thrombotic events disproportionately increase in the elderly.
  • Older patients often have comorbidities (diabetes, hypertension, hypercholesterolemia) that exacerbate risk.
  • Antithrombotic therapy is underutilized in geriatric populations, even when safe.

Purpose of the Study:

  • To review the efficacy and safety of antiplatelet agents in the elderly.
  • To assess the impact of antiplatelet therapy in various disease states within this demographic.
  • To highlight the underuse of antithrombotic treatments in geriatric patients.

Main Methods:

  • Review of available antiplatelet agents: aspirin, clopidogrel, and glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonists.
  • Analysis of clinical data focusing on the geriatric population.
  • Assessment of drug effects across different disease states relevant to the elderly.

Main Results:

  • Elderly patients exhibit a disproportionately higher risk of arterial ischemic events.
  • Comorbidities like diabetes, hypertension, and hypercholesterolemia significantly increase this risk.
  • Current antithrombotic therapy use in the elderly is suboptimal, irrespective of contraindications.

Conclusions:

  • Antiplatelet agents (aspirin, clopidogrel, GPIIb/IIIa antagonists) have a crucial role in managing thrombotic risk in the elderly.
  • Further research and clinical attention are needed to address the underutilization of these therapies in geriatric patients.
  • Optimizing antithrombotic strategies is essential for reducing arterial thrombotic events in the aging population.

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