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Alverine induced toxic hepatitis: a case report.
Ziyaettin Durakoğlu1, Güngör Boztaş, Ali Sezgil
1Istanbul University, Istanbul Medical Faculty, Department of Gastroenterohepatology, Capa. ziyadurakoglu@hotmail.com
Summary
Alverine, an antispasmodic drug, can cause liver injury (hepatotoxicity) and bile flow blockage (cholestasis). This rare side effect is important to recognize in patients with irritable bowel syndrome.
Area of Science:
- Hepatology
- Pharmacology
- Gastroenterology
Background:
- Drug-induced liver injury is a significant clinical concern.
- Alverine is an antispasmodic commonly prescribed for irritable bowel syndrome.
- Hepatotoxicity from alverine is rarely documented.
Purpose of the Study:
- To report a rare case of alverine-induced hepatotoxicity with cholestasis.
- To highlight the potential for liver injury from alverine use.
Main Methods:
- Case report presentation.
- Review of clinical presentation and laboratory findings.
Main Results:
- The patient developed liver injury and cholestasis attributed to alverine.
- This presentation of alverine hepatotoxicity is seldom reported in medical literature.
Conclusions:
- Alverine can cause significant liver injury, including cholestasis.
- Clinicians should consider alverine as a potential cause of hepatotoxicity in relevant patients.