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The PROSITE database.

Nicolas Hulo1, Amos Bairoch, Virginie Bulliard

  • 1Swiss Institute of Bioinformatics (SIB), Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland. Nicolas.Hulo@isb-sib.ch

Nucleic Acids Research
|December 31, 2005
PubMed
Summary
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The PROSITE database offers protein signatures as patterns and profiles, enhancing biological information. Recent updates improved documentation and web functionalities, increasing its integration with UniProtKB/Swiss-Prot.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Proteomics

Background:

  • The PROSITE database is a crucial resource for protein sequence analysis.
  • It contains biologically significant signatures, including patterns and profiles, linked to detailed documentation.
  • These signatures help identify protein families, domains, and functional sites.

Purpose of the Study:

  • To update on the latest developments and content of the PROSITE database.
  • To highlight improvements in documentation and web functionalities.
  • To report on the database's integration with UniProtKB/Swiss-Prot.

Main Methods:

  • Database curation and content expansion.
  • Redesign of documentation and ScanProsite web pages.
  • Integration with UniProtKB/Swiss-Prot through cross-references.

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Main Results:

  • The latest PROSITE release (19.11) contains 1329 patterns and 552 profile entries.
  • Over 200 new domains were added in the past two years.
  • 52% of UniProtKB/Swiss-Prot entries now cross-reference PROSITE.

Conclusions:

  • PROSITE continues to be a vital and expanding resource for protein analysis.
  • Enhanced documentation and web tools improve usability and accessibility.
  • Increased integration signifies its importance in the broader proteomic landscape.