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PHI-base: a new database for pathogen host interactions.

Rainer Winnenburg1, Thomas K Baldwin, Martin Urban

  • 1Biomathematics and Bioinformatics Division, Rothamsted Research, Harpenden, AL5 2JQ, UK.

Nucleic Acids Research
|December 31, 2005
PubMed
Summary
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PHI-base is a new database cataloging fungal and Oomycete pathogen genes. It aids researchers in identifying virulence factors for developing new disease control strategies.

Area of Science:

  • Mycology and Plant Pathology
  • Microbial Pathogenesis
  • Bioinformatics

Background:

  • Increasing number of verified genes related to pathogenicity and host response.
  • Need for a centralized resource for fungal and Oomycete pathogen genes.
  • Limited availability of curated data on virulence factors and host interactions.

Purpose of the Study:

  • To develop PHI-base, a web-accessible database of experimentally verified pathogenicity, virulence, and effector genes.
  • To provide a comprehensive resource for fungal and Oomycete pathogens.
  • To facilitate the discovery of novel targets for disease intervention.

Main Methods:

  • Cataloging 405 genes from 54 fungal and Oomycete pathogens.
  • Curating entries with experimental evidence (gene/transcript disruption) and literature references.

Related Experiment Videos

  • Annotating genes using controlled vocabularies and linking to external databases.

    • Main Results:

    • PHI-base currently contains 405 verified genes from 54 pathogens.
    • Data includes nucleotide/amino acid sequences and functional descriptions.
    • 176 genes from animal pathogens, 227 from plant pathogens, and 3 from fungal hosts are cataloged.

    Conclusions:

    • PHI-base is the first online resource for fungal and Oomycete pathogenicity genes and host interactions.
    • It serves as a valuable resource for identifying targets for therapeutic and agricultural interventions.
    • The database is freely accessible and welcomes new data contributions.