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Risk factors for poor collateral development in claudication.

Salvatore De Vivo¹, Ulrika Palmer-Kazen, Bo Kalin

¹Department of Vascular Surgery, Karolinska Hospital, Stockholm, Sweden.

Vascular and Endovascular Surgery

|December 31, 2005

Summary

Diabetes and short symptom duration are linked to poor collateral vessel development in patients with superficial femoral artery occlusion and claudication. This impacts blood flow and walking ability.

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Area of Science:

Vascular Surgery
Interventional Radiology
Cardiovascular Disease

Background:

Peripheral artery disease (PAD) affects lower limb circulation.
Claudication is a common symptom of PAD, often caused by superficial femoral artery (SFA) occlusion.
Collateral circulation is vital for blood flow restoration in occluded arteries.

Purpose of the Study:

To identify risk factors for inadequate collateral vessel formation in patients experiencing calf claudication.
To analyze the relationship between patient characteristics and the number of collateral vessels bypassing SFA occlusion.

Main Methods:

Retrospective, cross-sectional study of 45 patients with SFA occlusion and calf claudication.
Angiographic assessment of collateral vessels, ankle-brachial index (ABI), and outflow vessel patency.

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Regression analysis to determine factors associated with collateral count.

Main Results:

Mean collateral count was 15.1.
Univariate analysis showed associations between fewer collaterals and diabetes, short symptom duration, smoking, and older age.
Multivariate analysis identified diabetes and short symptom duration as independent predictors of fewer collaterals.

Conclusions:

Diabetes and a shorter duration of symptoms are significantly associated with poor collateral development in patients with SFA occlusion and claudication.
These findings highlight key patient factors influencing the body's ability to compensate for blocked arteries.