[Creatine phosphate as a drug in acute myocardial infarct]

The reserves of endogenous creatine phosphate are very rapidly exhausted in ischaemia. This leads at first to reversible and later to irreversible cell damage. Creatine phosphate can be administered in the preparation Neoton. It serves not only as a source of energy after arrest of oxidative phosphorylation; its main effect is stabilization of sarcolemma and protection against its disintegration. Several publications provide evidence of its favourable effect on the protection of the heart muscle during operations on the open heart, on a reduced incidence of ventricular arrhythmias in acute myocardial infarction and improvement in chronic cardiac insufficiencies. In Czechoslovakia multicentre clinical studies are under way testing Neoton in cardiological indications.