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Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics.
Irene Pasquali1, Ruggero Bettini, Ferdinando Giordano
1Department of Pharmacy, University of Parma, Italy.
Summary
Supercritical fluid technologies offer innovative particle engineering strategies for pharmaceuticals. These methods control solid-state properties, morphology, and particle size, meeting regulatory demands for purity and environmental safety.
Area of Science:
- Pharmaceutical Sciences
- Chemical Engineering
- Materials Science
Background:
- Particle engineering is crucial for drug product development.
- Traditional methods face challenges in controlling solid-state properties and morphology.
- Increasing regulatory scrutiny demands advanced characterization and purity standards.
Purpose of the Study:
- To review modern and innovative particle engineering strategies using supercritical fluid technologies.
- To highlight the role of supercritical fluids in controlling solid-state chemistry aspects.
- To emphasize the potential of these technologies for 21st-century drug development.
Main Methods:
- Review of supercritical fluid technologies for particle production.
- Focus on solid-state chemistry principles.
- Analysis of industrial-scale applications.
Main Results:
- Supercritical fluid processes effectively control solid-state, morphology, and particle size of pharmaceuticals.
- These technologies are suitable for industrial-scale production.
- They offer a pathway to meet stringent regulatory requirements.
Conclusions:
- Supercritical fluid technologies are prominent for advanced drug product development.
- They enable precise control over critical quality attributes.
- This approach supports enhanced purity and environmental acceptability in pharmaceutical manufacturing.