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Methylene blue-mediated photodynamic therapy: a possible alternative treatment for oral lichen planus
Farzane Aghahosseini1, Fateme Arbabi-Kalati, Leila Ataie Fashtami
1Oral Medicine Department, Faculty of Dentistry, Tehran University of Medical Sciences, TUMS, Tehran, Iran.
Background And Objectives:
In this study, methylene blue-mediated photodynamic therapy (MB-PDT) was used as a possible alternative method for the treatment of oral lichen planus (OLP).
Study Design/Materials And Methods:
Thirteen patients with 26 OLP lesions were enrolled in this study. Patients were instructed to gargle a 5% methylene blue solution in water for 5 minutes. Ten minutes later, irradiation was performed by laser light (lambda = 632 nm, light exposure dose = 120 J/cm(2)). Lesions were evaluated pre and post-operatively and at follow-up sessions by changes in sign and symptom (pain) scores, and size of lesions.
Results:
Improvement in sign scores was achieved in 16 lesions. Four keratotic lesions disappeared completely. There was a statistically significant decrease in sign and symptom scores 1 week after treatment and at follow-up sessions up to 12 weeks. Average reduction in size of lesions was 44.3%.
Conclusion:
MB-PDT seems to be an effective alternative treatment for control of OLP. In our opinion, this preliminary result warrant further studies in order to show the efficacy of MB-PDT in control of OLP for a longer period of time.
