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Updated: Aug 13, 2026

A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss
Published on: April 11, 2025
[Adaptation to central scotoma. Part II. Perceptual filling-in phenomenon]
1Centre d'Imagerie et de Laser, Paris. sycohen@club-internet.fr
Abstract:
The visual cortex may reorganize after occurrence of a scotoma. Different experimental studies have shown that there is an attempt to minimize the impact of the scotoma, the missing information being filled-in by surrounding information. The clinical consequences of this filling-in phenomenon have been extensively studied by Safran and co-workers. The present review summarizes the current literature on this phenomenon and its clinical consequences. Furthermore, the authors present their own experience with the filling-in phenomenon in patients with age-related macular degeneration. Their study shows that, with few exceptions, the phenomenon only occurs in patients with bilateral central scotoma, in their better eye.
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