Related Experiment Video
Updated: Aug 13, 2026
09:52
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
Published on: April 19, 2013
CDKN2A common variant and multi-organ cancer risk--a population-based study
Tadeusz Debniak1, Rodney J Scott, Tomasz Huzarski
1Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. debniak@wp.pl
International Journal of Cancer
|January 6, 2006
Summary
The CDKN2A A148T variant is more common in Polish lung cancer patients. This common variant may increase the risk for multiple cancers in the Polish population, warranting further investigation.
Area of Science:
- Genetics
- Oncology
- Population Studies
Background:
- The population frequencies of common CDKN2A variants are largely unknown.
- A specific CDKN2A variant, A148T (alanine to threonine substitution), is prevalent in Poland.
- Previous research indicated this variant is overrepresented in Polish melanoma patients.
Purpose of the Study:
- To determine the prevalence of the CDKN2A A148T variant in a large Polish cohort.
- To investigate the association between the A148T variant and various cancer types in Poland.
Main Methods:
- Genotyping of the CDKN2A A148T variant in 3,583 unselected cancer cases.
- Genotyping of the CDKN2A A148T variant in 3,000 random control subjects from the Polish population.
- Analysis of eleven common cancer types.
Main Results:
- A significant positive association was found between the A148T variant and lung cancer (OR, 2.0; p = 0.0052).
- A trend towards association was observed for colorectal cancer (OR, 1.5; p = 0.5499), though not statistically significant after correction.
- The variant's prevalence was assessed across multiple common cancer sites.
Conclusions:
- The CDKN2A A148T variant is associated with an increased risk of lung cancer in the Polish population.
- The findings suggest a potential role for the A148T variant in multi-organ cancer susceptibility.
- Further research is needed to elucidate the full impact of this variant on cancer risk.
Related Concept Videos
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...