Related Experiment Video
Updated: Aug 13, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Reflux esophagitis in three cats associated with metaplastic columnar esophageal epithelium
Massimo Gualtieri1, Daniela Olivero
1Department of Veterinary Clinical Science, University of Milan, Milano, Italy.
Abstract:
Gastroesophageal reflux is a relatively common condition in dogs and cats and may lead to secondary reflux esophagitis. A consequence of chronic gastroesophageal reflux that is well described in humans is Barrett's esophagus, which is the replacement of the normal squamous epithelium of the distal esophagus with metaplastic columnar epithelium. Three cats with clinical and endoscopic signs of chronic esophagitis had metaplastic columnar epithelium on biopsy of the distal esophageal mucosa. Suspected underlying causes were cardial incompetence and sliding hiatal hernia. Two cats had complete resolution of the clinical signs after treatment. One cat was euthanized.
More Related Videos
Related Concept Videos
Barrett Esophagus-I: Introduction
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Esophageal Achalasia
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Cellular Adaptation IV: Dysplasia and Metaplasia
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

