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Reversed-phase high-performance liquid chromatography-thermospray mass spectrometry of radiation-induced
1Laboratoire Lésions des Acides Nucléiques, DRFMC/SESM, Centre d'Etudes Nucléaires, Grenoble, France.
Journal of Chromatography
|February 28, 1992
Abstract:
High-performance liquid chromatography-thermospray mass spectrometry was applied to the analysis of various radiation-induced decomposition products of thymidine including N-(2-deoxy-beta-D-erythro-pentofuranosyl)formamide and the various diastereomers of 5,6-dihydroxy-5,6-dihydrothymidine, 5-hydroxy-5,6-dihydrothymidine and 5,6-dihydrothymidine. This method combines high sensitivity and product resolution, rendering it particularly useful for monitoring the formation of radiation-induced base damage within DNA.