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Injectable bioglass as a potential substitute for injectable polytetrafluoroethylene
R D Walker1, J Wilson, A E Clark
1Department of Surgery, University of Florida, Gainesville.
The Journal of Urology
|August 1, 1992
Summary
Bioglass particles in sodium hyaluronate show promise as a safe injectable biomaterial. This new material may offer a viable alternative for treating urinary incontinence and vesicoureteral reflux.
Area of Science:
- Biomaterials Science
- Urology
- Regenerative Medicine
Background:
- Injectable polytetrafluoroethylene (Teflon) and collagen present challenges for long-term efficacy.
- A need exists for alternative injectable biomaterials in urological applications.
Purpose of the Study:
- To evaluate the safety and efficacy of Bioglass particles suspended in sodium hyaluronate as an injectable biomaterial.
- To assess the potential of this Bioglass suspension for treating conditions like urinary incontinence and vesicoureteral reflux.
Main Methods:
- Safety of Bioglass particles in sodium hyaluronate was confirmed in rabbit models.
- The ability of the Bioglass suspension to enhance urethral resistance was tested in pigs.
Main Results:
- Injected Bioglass particles suspended in sodium hyaluronate demonstrated safety in rabbits.
- The Bioglass suspension effectively increased urethral resistance in pigs, indicating functional potential.
Conclusions:
- Bioglass particles suspended in sodium hyaluronate represent a potentially safe and effective injectable biomaterial.
- This novel formulation shows promise as a substitute for existing materials in treating urinary incontinence and vesicoureteral reflux.