Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metal carcinogenesis: mechanistic implications.

E T Snow1

  • 1Nelson Institute of Environmental Medicine, New York University Medical Center, Tuxedo 10987.

Pharmacology & Therapeutics
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arsenic and heavy metal contamination of vegetables grown in Samta village, Bangladesh.

The Science of the total environment·2003
Same author

A comparison of trace element concentrations in cultured and wild carp (Cyprinus carpio) of Lake Kasumigaura, Japan.

Ecotoxicology and environmental safety·2002
Same author

In vitro effect of arsenical compounds on glutathione-related enzymes.

Chemical research in toxicology·2001
Same author

Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes.

Mutation research·1998
Same author

Chromium(III) decreases the fidelity of human DNA polymerase beta.

Biochemistry·1998
Same author

The role of DNA repair in development.

Reproductive toxicology (Elmsford, N.Y.)·1997
Same journal

Protein acetylation modification in tissue fibrosis: Opportunities and challenges.

Pharmacology & therapeutics·2026
Same journal

Nipocalimab and other FcRn blockers in neuromuscular disorders.

Pharmacology & therapeutics·2026
Same journal

C26:0-lysophosphatidylcholine in X-linked adrenoleukodystrophy.

Pharmacology & therapeutics·2026
Same journal

The CircRNA/miRNA axis in breast cancer: From molecular mechanisms to clinical translation.

Pharmacology & therapeutics·2026
Same journal

Glymphatic-meningeal lymphatic dysfunction in epilepsy: novel mechanistic insights and therapeutic avenues.

Pharmacology & therapeutics·2026
Same journal

The neurovascular unit under siege: Molecular mechanisms and potential drug target for cerebral edema.

Pharmacology & therapeutics·2026
See all related articles

Several metal compounds are carcinogenic, inducing genotoxicity through various mechanisms like oxidative stress and DNA repair inhibition. This review details the genotoxic effects of arsenic, chromium, nickel, beryllium, and cadmium in cancer development.

Area of Science:

  • Environmental Health
  • Toxicology
  • Carcinogenesis

Background:

  • Metal compounds are recognized human carcinogens in cancer epidemiology.
  • Emerging evidence indicates carcinogenic metals induce genotoxicity via multiple pathways.
  • These metals can act independently or potentiate the effects of other carcinogens.

Purpose of the Study:

  • To review current knowledge on the genotoxicity of specific metal compounds.
  • To explore the potential roles of these metals in carcinogenesis.
  • To highlight common and distinct genotoxic mechanisms.

Main Methods:

  • Literature review of genotoxicity studies on metal compounds.
  • Analysis of data on arsenic, chromium, nickel, beryllium, and cadmium.

Related Experiment Videos

  • Synthesis of information on mechanisms of action.

    • Main Results:

    • Arsenic, chromium, nickel, beryllium, and cadmium compounds exhibit distinct genotoxic profiles.
    • Common genotoxic mechanisms include induction of oxidative stress and cellular immune responses.
    • Inhibition of DNA metabolism and repair, and formation of DNA/protein crosslinks are also observed.

    Conclusions:

    • These metals contribute to carcinogenesis through diverse genotoxic mechanisms.
    • Understanding these mechanisms is crucial for risk assessment and prevention.
    • Further research into metal-induced genotoxicity is warranted.