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Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes
Published on: August 9, 2011
Listeria monocytogenes as a probe of immune function
Oleg Garifulin1, Victor Boyartchuk
1Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA.
Briefings in Functional Genomics & Proteomics
|January 20, 2006
Summary
The mouse model of Listeria monocytogenes infection is a valuable tool for studying immunity. Researchers use it to analyze immune responses and discover new immune genes using genetics and genomics.
Area of Science:
- Immunology
- Microbiology
- Genetics
Background:
- The mouse model of Listeria monocytogenes infection has been instrumental for nearly 50 years in understanding immunity.
- Extensive data on this disease model in mice offers a robust framework for immune molecule discovery.
Purpose of the Study:
- To provide an overview of how modern genetics and genomics can be applied to study immune signaling networks.
- To highlight the utility of the mouse model for dissecting complex immune responses.
Main Methods:
- Utilizing the established mouse model of Listeria monocytogenes infection.
- Applying advanced genetics and genomics tools for analysis.
- Investigating components of immune signaling pathways.
Main Results:
- Demonstrated the broad applicability of the mouse model for immunological research.
- Showcased the power of genetic and genomic approaches in identifying immune molecules.
- Provided insights into immune signaling networks.
Conclusions:
- The mouse model remains a critical platform for immunological research and gene discovery.
- Genetics and genomics significantly enhance the ability to characterize immune components.
- Further research can leverage this model to unravel intricate immune mechanisms.
