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Soluble adhesion molecules ICAM-1, VCAM-1, P-selectin in children with Helicobacter pylori infection

Elzbieta Maciorkowska1, Maciej Kaczmarski, Anatol Panasiuk

  • 1Department of Pediatric Nursing, Medical University of Bialystok, Waszyngtona Str., 15, 15-274 Bialystok, Poland. emaciorkowska@o2.pl

World Journal of Gastroenterology
|January 21, 2006
PubMed

Insights

In children with Helicobacter pylori infection, serum soluble VCAM-1 (sVCAM-1) levels are elevated and correlate with gastric inflammation. These levels decrease after H. pylori eradication, unlike sP-selectin and sICAM-1.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Immunology

Background:

  • Helicobacter pylori (H. pylori) infection is a common cause of gastritis in children.
  • Adhesive molecules play a role in inflammatory processes within the gastric mucosa.
  • Understanding the role of specific biomarkers like sICAM-1, sVCAM-1, and sP-selectin in H. pylori-associated gastritis is crucial.

Purpose of the Study:

  • To quantify serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble P-selectin (sP-selectin) in children with H. pylori infection.
  • To investigate the association between these adhesion molecule levels and the severity of morphological changes in gastric mucosa.
  • To evaluate the changes in these markers following H. pylori eradication.

Main Methods:

  • A cohort of 106 children was studied, categorized by H. pylori infection status and gastritis presence.
  • Gastric mucosal evaluation was performed using endoscopic and histopathological assessments based on the Sydney System.
  • Serum levels of sP-selectin, sICAM-1, and sVCAM-1 were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) technique.

Main Results:

  • Gastritis activity showed statistically significant degrees in the antrum and corpus of the examined children (P<0.001).
  • Serum sVCAM-1 levels were significantly higher in children with H. pylori-induced gastritis compared to uninfected children (P<0.05).
  • Serum sVCAM-1 was the most elevated adhesion molecule in infected children and decreased post-eradication; sICAM-1 and sP-selectin levels were similar across groups.

Conclusions:

  • Elevated serum sVCAM-1 in children with active H. pylori infection indicates its involvement in the pathogenesis of gastric mucosal inflammation.
  • sVCAM-1 levels decrease after successful H. pylori eradication.
  • sP-selectin and sICAM-1 serum concentrations do not show significant differences in children with H. pylori infection post-eradication compared to healthy controls.
Abstract

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