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Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor
Selim Suner1, Matthew R Fellows, Carlos Vargas-Irwin
1Department of Emergency Medicine and Surgery, Brown University, Providence, RI 02912, USA. selim_suner@brown.edu
Summary
Reliable neural recordings were achieved using microelectrode arrays in monkey motor cortex for up to 1.5 years. These findings support long-term use of brain-computer interfaces for restoring movement in paralyzed individuals.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Rehabilitation Technology
Background:
- Neuromotor prosthetic devices aim to restore function in paralyzed individuals.
- Long-term reliability of neural recording arrays is crucial for prosthetic applications.
Purpose of the Study:
- To evaluate the long-term reliability of a 100-microelectrode array for neural recordings in the primary motor cortex (MI) of non-human primates.
- To assess the signal quality and stability of neural recordings over extended periods for potential use in brain-computer interfaces.
Main Methods:
- Implanted silicon probe arrays in the MI of three Macaque monkeys.
- Recorded neural signals during a motor task over periods up to 1.5 years.
- Assessed recording reliability using qualitative (signal quality scale) and quantitative (signal-to-noise ratio) measures.
Main Results:
- Over 80% of recorded neural signals were of high quality across multiple sessions and subjects.
- Signal quality remained stable over the evaluation period, with mean signal-to-noise ratios up to 20.
- 66% of recorded neurons showed tuning to reach direction, indicating movement-related information.
Conclusions:
- Monolithic microelectrode arrays provide reliable, long-term neural recordings from primate MI.
- These findings support the use of such arrays for both fundamental neuroscience research and the development of neural prostheses.