Related Experiment Video
Updated: Aug 13, 2026
High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes
Published on: July 25, 2015
Hairy cell leukemia: a diagnosis by endoscopic ultrasound guided fine needle aspiration
Regina S Meara1, Vishnu Reddy, Juan Pablo Arnoletti
1Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. rschmidt@path.uab.edu
Background:
Endosonography (EUS) guided FNA is a relatively new imaging modality which is increasingly used for sampling deep-seated lymph nodes in the diagnosis and staging of various malignancies, both primary as well as metastatic. It is also useful for staging of non-Hodgkin's lymphoma as well as diagnosing recurrence. The diagnosis of leukemia on FNA samples from deep-seated lymphadenopathy poses an even greater challenge. Hairy cell leukemia (HCL) is an uncommon, but distinct, lympho-proliferative disorder of B cell origin. It usually affects the spleen and bone marrow and uncommonly involves lymph nodes. There are only a few cases reported where HCL was diagnosed on FNA specimens.
Case Presentation:
We report the first case of HCL accurately rendered on EUS-FNA samples.
Conclusion:
This report underscores the concept that the presence of a cytopathologist in the endoscopy suite plays an important role in providing accurate diagnoses of lymphoid lesions biopsied with EUS-FNA.
