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Updated: Aug 13, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
Published on: August 9, 2019
HuR, an RNA-binding protein, involved in the control of cellular differentiation
Joy Cherry1, Vesna Karschner, Heath Jones
1Department of Biochemistry and Molecular Biology, The Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
Abstract:
HuR is an RNA-binding protein that resides predominantly in the nucleus but shuttles to the cytosol carrying mRNAs containing a uridylate-rich region in the 3'untranslated region. Data suggest that HuR is involved in the control of the differentiation process through a tightly regulated selection of mRNAs to be shuttled to the cytosol for translation. In this review, the function of HuR in the differentiation process of preadipocytes is examined in the context of specific mRNAs selected by HuR for translocation to the cytosol.
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Transcription
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...

