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Quantitative thermal sensory testing in patients with monomelic amyotrophy
1Department of Neurology, All India Institute of Medical Sciences, Cardiothoracic and Neurosciences Centre, Ansari Nagar, New Delhi-110029. d_joshi73@yahoo.co.in
Electromyography and Clinical Neurophysiology
|January 28, 2006
Summary
Quantitative thermal sensory testing (QST) found no small fibre dysfunction in monomelic amyotrophy (MMA) patients. This suggests MMA is purely a motor disorder, without sensory nerve involvement.
Area of Science:
- Neurology
- Neurophysiology
Background:
- Quantitative thermal sensory testing (QST) assesses small fibre dysfunction, not covered by routine nerve conduction studies (NCS).
- Monomelic amyotrophy (MMA) is a motor disorder with normal NCS, but its sensory function remains unevaluated by QST.
Purpose of the Study:
- To investigate potential somatic small fibre involvement in MMA patients using QST.
- To compare thermal sensory thresholds in MMA patients with healthy controls.
Main Methods:
- Forty MMA patients and 40 age-matched controls underwent QST.
- Thermal sensory thresholds for cold sensation (CS), warm sensation (WS), cold pain (CP), and warm pain (WP) were measured using the method of limits.
Main Results:
- No significant differences in CS, WS, CP, or WP thresholds were observed between MMA patients and controls.
- QST did not reveal any sensory abnormalities in the MMA group.
Conclusions:
- QST results indicate no involvement of somatic small sensory fibres (A delta and C) in MMA.
- The findings support the classification of MMA as a pure motor disorder.
