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Updated: Jan 20, 2026
Solid Phase Synthesis: Principles, Peptide Synthesis
Published on: April 29, 2023
Solid-phase synthesis with resin-bound triarylbismuthanes: traceless and multidirectional cleavage of unsymmetrical
L Kyhn Rasmussen1, Mikael Begtrup, Thomas Ruhland
1Department of Medicinal Chemistry, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark.
Abstract:
A multistep solid-phase organic synthesis with resin-bound bismuth linker is described. The flexibilities inherent in this system through novel chemoselective cross-coupling reactions, in conjunction with multidirectional and/or traceless cleavage methodologies, are exploited.
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