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The WD-40 repeat
1Division of Cellular Biochemistry, Netherlands Cancer Institute, Amsterdam.
FEBS Letters
|July 28, 1992
Summary
The WD-40 repeat is found in many proteins, but its function is unknown. These proteins may interact with TPR-family proteins via their respective repeats.
Area of Science:
- Molecular Biology
- Protein Science
Background:
- WD-40 repeats are common in diverse proteins with no clear shared function.
- The function of WD-40 repeats remains largely unknown across various protein families.
- Tetratricopeptide repeats (TPR) are another motif found in protein families with unknown function.
Purpose of the Study:
- To explore the potential functional relationship between WD-40 repeats and TPR-family proteins.
- To investigate the possibility of physical interactions between these two types of protein repeats.
Main Methods:
- Analysis of existing protein sequence data to identify WD-40 repeat-containing proteins.
- Review of recent yeast genetic association studies linking WD-40 repeat proteins with TPR-family members.
Main Results:
- WD-40 repeats are present in a wide array of proteins lacking obvious functional similarities.
- Genetic association data from yeast suggests a link between WD-40 repeat proteins and TPR-family proteins.
Conclusions:
- Proteins containing WD-40 repeats and TPR-family proteins may interact physically.
- The respective repeat motifs (WD-40 and TPR) are hypothesized as the interaction sites.
- This suggests a potential conserved mechanism of interaction between these protein families.