[Humoral mechanisms of autoimmune process against type I collagen in psoriasis]

Psoriasis represents disease with the involvement autoimmune mechanism against type I collagen, and its degree depends on the form of the disease and its clinical course. There is direct association between the autoantibody titres against type I collagen and the severity of the disease. As developed autoimmune process against type I collagen is specific in traditional treatment process, in spite of definite clinic effectiveness, without usage of specific factors there is no involution in autoimmune process against type I collagen. 134 patients with psoriasis have been investigated. 94 of them had vulgar psoriasis, 20 had erythrodermal form and 20 had arthropatic form. 50 healthy subjects were included in the control group. The age of patients varied from 20 to 70 years. It is confirmed that by treatment using miolophid immunomodulation autoantibody against type I collagen has decreased and treatment was relatively effective. It should be mentioned that despite immunomodulation therapy and achieved effect, there is no complete involution of autoimmune process, as in the case of psoriasis clinical and biological recovery periods do not coincide and thus after discharging from hospital prognosis must be controlled by measuring of autoantibody titres.