Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spermatogonial stem cells: questions, models and perspectives.

Jens Ehmcke1, Joachim Wistuba, Stefan Schlatt

  • 1Department of Cell Biology and Physiology, Center for Research in Reproductive Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Human Reproduction Update
|February 1, 2006
PubMed
Summary

This review explores spermatogonial stem cell phylogeny and physiology, highlighting species-specific differences. It proposes new models for stem cell behavior and spermatogenesis, suggesting primates may have true stem cells, unlike rodents.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Normal spermatogenesis in older men is associated with compensatory transcriptome changes.

GeroScience·2026
Same author

Assessing a Model for a Complex Systemic Disorder-The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research.

Andrology·2026
Same author

Bicarbonate buffer enhances functional sperm selection compared to Zwitterionic buffers in sperm preparation.

Scientific reports·2026
Same author

The topographical distribution of spermatogonial subpopulations during the cycle of seminiferous epithelium in Macaca Fascicularis.

Biology of reproduction·2026
Same author

Optical tissue clearing and 3D imaging of intact primate testicular tissue: a novel technology development.

PloS one·2025
Same author

EndoCompass Project: Research Roadmap for Reproductive and Developmental Endocrinology.

Hormone research in paediatrics·2025

Area of Science:

  • Reproductive Biology
  • Stem Cell Biology
  • Evolutionary Biology

Background:

  • Spermatogonial stem cells (SSCs) are crucial for continuous sperm production.
  • Understanding SSC physiology is key to reproductive health and therapies.
  • Species-specific variations in SSC behavior are not fully elucidated.

Purpose of the Study:

  • To review the phylogeny and basic biology of SSCs.
  • To analyze species-specific differences in SSC physiology.
  • To propose revised models for SSC clonal expansion and spermatogenesis.

Main Methods:

  • Literature review focusing on SSC phylogeny and physiology.
  • Comparative analysis of SSC behavior across species.
  • Development of new conceptual models for spermatogonial dynamics.

Related Experiment Videos

Main Results:

  • Revised models for clonal expansion of spermatogonia.
  • Proposed distinction between true stem cells and progenitors in primates, absent in rodents.
  • New model for species-specific arrangements of spermatogenic stages based on clonal expansion.

Conclusions:

  • SSC physiology exhibits significant species-specific differences.
  • Primate SSC models may differ fundamentally from rodent models.
  • Germ cell transplantation is a valuable tool for SSC research and potential clinical applications.