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Related Experiment Videos

Anabolic steroids: a fatal attraction?

Ruth I Wood1

  • 1Keck School of Medicine University of Southern California Los Angeles, CA, USA.

Journal of Neuroendocrinology
|February 4, 2006
PubMed
Summary

Anabolic-androgenic steroids (AAS) show addictive potential in hamsters, indicated by voluntary self-administration and fatal overdoses. These findings suggest AAS may be addictive independent of performance-enhancing effects.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Endocrinology

Background:

  • Anabolic-androgenic steroids (AAS) abuse is prevalent.
  • The addictive potential of AAS remains poorly understood.
  • Previous research indicates AAS affect the brain.

Purpose of the Study:

  • To investigate the addictive potential of AAS.
  • To determine if AAS self-administration leads to dependence.
  • To assess AAS abuse liability in a preclinical model.

Main Methods:

  • Male and female hamsters were used.
  • Voluntary self-administration of testosterone and other AAS was studied.
  • Dosage and overdose effects were monitored.

Main Results:

  • Hamsters voluntarily self-administered AAS.
  • Fatal androgen overdose occurred during self-administration.
  • Behavioral patterns suggest compulsive drug-seeking.

Conclusions:

  • AAS demonstrate abuse liability in preclinical models.
  • The addictive properties of AAS are independent of anabolic or androgenic effects.
  • Findings support the classification of AAS as potentially addictive substances.

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