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Updated: Aug 11, 2026

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Solid-phase chemistry in the total synthesis of non-peptidic natural products
Pablo Cironi1, Mercedes Alvarez, Fernando Albericio
1Biomedical Research Institute, Barcelona Scientific Park-University of Barcelona, 08028 Barcelona, Spain. pablo_cironi@dfci.harvard.edu
Abstract:
Solid-phase chemistry, first introduced for peptide synthesis in the 1960's, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.
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