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Citrate-reduced silver hydrosol modified with omega-mercaptoalkanoic acids self-assembled monolayers as a substrate
Alois Bonifacio1, Lineke van der Sneppen, Cees Gooijer
1Laser Centre, Analytical Chemistry and Applied Spectroscopy, Vrije Universiteit, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands.
Abstract:
A new citrate-reduced silver hydrosol coated with omega-mercaptoalkanoic acids (mercaptopropionic and mercaptoundecanoic acids) self-assembled monolayers was prepared and characterized with surface-enhanced Raman spectroscopy. The structure and the quality of the coating monolayers are discussed and compared to similar coated and uncoated silver hydrosols previously developed. As an application, the new hydrosol was used as a biocompatible and efficient metal substrate for a surface-enhanced resonance Raman scattering (SERRS) study of cytochrome c. The high-quality SERRS spectra reported of cytochrome c (obtained using only 1 microL of a micromolar cytochrome solution) are discussed and compared with data available from literature studies.
