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Related Experiment Videos

An introduction to TRP channels.

I Scott Ramsey1, Markus Delling, David E Clapham

  • 1Howard Hughes Medical Institute, Cardiovascular Department, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA. sramsey@enders.tch.harvard.edu

Annual Review of Physiology
|February 8, 2006
PubMed
Summary
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Mammalian transient receptor potential (TRP) channels are calcium-permeable and polymodally activated, playing roles in cellular sensation and guidance. This review outlines their function, subfamilies, and properties.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Neuroscience

Background:

  • Mammalian transient receptor potential (TRP) channels are a family of six-transmembrane cation channels.
  • They are classified into six subfamilies based on sequence homology: TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML.
  • TRP channels are crucial for cellular sensation and signal transduction.

Purpose of the Study:

  • To provide a framework for understanding the function of mammalian TRP channels.
  • To summarize functional properties of TRP channels from each subfamily.
  • To explore the role of TRP channels in neuronal growth cone steering and cellular guidance.

Main Methods:

  • Review of existing literature on mammalian TRP channels.
  • Analysis of functional properties elucidated in heterologous expression systems.

Related Experiment Videos

  • Summary of TRP channel gene family, nomenclature, protein variants, and pharmacology.

    • Main Results:

    • TRP channels are generally calcium-permeable cation channels with polymodal activation.
    • They integrate multiple stimuli and amplify cellular signals via calcium permeation and depolarization.
    • TRP channels are implicated in neuronal growth cone steering and may function in cellular chemotaxis.

    Conclusions:

    • TRP channels are essential for cellular sensation and guidance mechanisms.
    • Their polymodal activation and signaling roles highlight their adaptability in cellular processes.
    • Further research into TRP channel function in cellular guidance and chemotaxis is warranted.