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Activity-based high-throughput profiling of metalloprotease inhibitors using small molecule microarrays

Jun Wang1, Mahesh Uttamchandani, Li Ping Sun

  • 1Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore.

Chemical Communications (Cambridge, England)
|February 9, 2006
PubMed

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...