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Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats.

B R Olson1, M D Drutarosky, M S Chow

  • 1Department of Medicine, University of Pittsburgh, PA 15261.

Peptides
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Oxytocin (OT) administered centrally reduces food intake in rats by acting on brain receptors. Tolerance to this effect can be prevented by blocking OT receptors.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Behavioral Science

Background:

  • Oxytocin (OT) is a neuropeptide involved in social behaviors and has been implicated in regulating feeding behaviors.
  • The precise role of central OT in appetite regulation remains to be fully elucidated.

Purpose of the Study:

  • To investigate the role of central oxytocin receptors in the inhibition of food intake in rats.
  • To examine the development of tolerance to OT's anorectic effects and the potential involvement of OT antagonists.

Main Methods:

  • Intracerebroventricular (ICV) administration of oxytocin, an OT agonist, and an OT antagonist in fasted rats.
  • Dose-response studies were conducted to assess the effects on food intake and grooming behavior.
  • Tolerance development and the effect of OT antagonist pretreatment were evaluated with repeated ICV injections.

Related Experiment Videos

Main Results:

  • ICV oxytocin and an OT agonist dose-dependently decreased food intake in fasted rats.
  • Central OT administration increased grooming behavior but did not induce dyskinesias.
  • Tolerance to OT's anorectic effect developed by the third day of treatment, which was prevented by co-administration of an OT antagonist.
  • The anorectic effects were central, not associated with altered plasma hormones or blood glucose levels.

Conclusions:

  • Specific oxytocin receptors within the central nervous system play a significant role in inhibiting feeding behavior in rats.
  • Central oxytocin receptor blockade can prevent the development of tolerance to OT's anorectic effects.