Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcranial magnetic stimulation and stroke: a computer-based human model study.

Tim Wagner1, Felipe Fregni, Uri Eden

  • 1Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. twagner@mit.edu

Neuroimage
|February 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aggrecan: Approaches to Study Biophysical and Biomechanical Properties.

Methods in molecular biology (Clifton, N.J.)·2021
Same author

Trypsin Pre-Treatment Combined With Growth Factor Functionalized Self-Assembling Peptide Hydrogel Improves Cartilage Repair in Rabbit Model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2019
Same author

The Effects of Waveform and Current Direction on the Efficacy and Test-Retest Reliability of Transcranial Magnetic Stimulation.

Neuroscience·2018
Same author

Relation of Anterior Cruciate Ligament Tears to Potential Chronic Cardiovascular diseases.

The American journal of cardiology·2018
Same author

Reduced motor cortex inhibition and a 'cognitive-first' prioritisation strategy for older adults during dual-tasking.

Experimental gerontology·2018
Same author

The Illusion of the Perfect Brain Enhancer.

Cerebrum : the Dana forum on brain science·2018
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
Same journal

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026
Same journal

Cognitive Strategy-based neuromodulation optimizes neural communication to improve working memory.

NeuroImage·2026
See all related articles

Transcranial magnetic stimulation (TMS) currents are significantly altered near stroke lesions. Conventional clinical standards for TMS are unreliable and potentially dangerous for stroke patients near the infarction site.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Stroke can cause significant anatomical and electrical changes in the brain.
  • Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique used in stroke rehabilitation.
  • The precise effects of stroke-induced brain changes on TMS efficacy are not fully understood.

Purpose of the Study:

  • To investigate how stroke-induced brain alterations affect TMS-induced electrical currents.
  • To evaluate the reliability of conventional TMS stimulation protocols in stroke patients.

Main Methods:

  • Construction of multiple MRI-derived finite element head models representing chronic stroke.
  • Comparison of TMS-induced currents in stroke models versus a healthy head model.

Related Experiment Videos

  • Analysis of current perturbations under various stimulation conditions and coil placements.

    • Main Results:

    • TMS-induced currents were significantly altered in magnitude, location, and orientation near stroke lesions.
    • Current perturbations were minimized when the TMS coil was positioned far from the lesion site.
    • Stimulation contralateral to the lesioned hemisphere showed minimal current alterations.

    Conclusions:

    • Conventional clinical standards for TMS are unreliable for predicting stimulation site and intensity in stroke patients.
    • Applying TMS proximal to an infarction site may lead to unpredictable and potentially dangerous outcomes.
    • Current findings highlight limitations of current TMS protocols in the context of stroke brain changes.