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Updated: Aug 11, 2026
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A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
Published on: May 21, 2010
Pontine and cerebellar atrophy correlate with clinical disability in SCA2
S H Ying1, S I Choi, S L Perlman
1Johns Hopkins University School of Medicine, Baltimore, MD, USA. sying@dizzy.med.jhu.edu
Neurology
|February 16, 2006
Abstract:
Spinocerebellar ataxia type 2 (SCA2) has protean manifestations, and a clinical marker of progression is needed. Although MRI is a promising tool, it is unclear whether the degree of atrophy shown on MRI is correlated with clinical dysfunction. Here the authors used high-resolution volumetric MRI analysis to show that cerebellar and pontine volumes specifically and closely correlate with functional staging scores.
