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Primary amyloidosis of the urinary bladder
Chao-Yuan Huang1, Chia-Tung Shun, Kuo-How Huang
1Department of Urology, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Journal of the Formosan Medical Association = Taiwan Yi Zhi
|February 16, 2006
Summary
Amyloidosis, a rare bladder condition, can mimic cancer with hematuria. Early diagnosis requires vigilance and special staining techniques for accurate identification and treatment.
Area of Science:
- Urology
- Pathology
- Oncology
Background:
- Amyloidosis is a systemic disease typically affecting the gastrointestinal or adipose tissues.
- Primary amyloidosis of the urinary bladder is rare and can present as painless gross hematuria, mimicking bladder cancer.
Observation:
- A 49-year-old male presented with recurrent gross hematuria, initially diagnosed as papillary urothelial hyperplasia.
- A subsequent presentation revealed papillary lesions and submucosal plaques, leading to a second resection.
Findings:
- Histologic examination confirmed amyloidosis of the urinary bladder with plasma cell infiltration and Congo red-positive deposits.
- Special staining techniques, including Congo red and polarized light microscopy, were crucial for diagnosis.
Implications:
- Amyloidosis should be considered in the differential diagnosis of unexplained recurrent hematuria, especially when bladder cancer is suspected but not confirmed.
- Early and accurate diagnosis of bladder amyloidosis is essential for appropriate patient management and to rule out malignancy.
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