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Unilateral uveitis in a dog with uveodermatologic syndrome
Kelly J Sigle1, Gillian J McLellan, Joseph S Haynes
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Journal of the American Veterinary Medical Association
|February 16, 2006
Summary
Uveodermatologic syndrome, a condition causing eye inflammation and skin depigmentation, can present unilaterally in dogs, even those with heterochromia irides. Early diagnosis is crucial for managing this autoimmune disease.
Area of Science:
- Ophthalmology
- Veterinary Dermatology
- Immunology
Background:
- Uveodermatologic syndrome (UDS) is an immune-mediated condition affecting ocular and cutaneous tissues.
- Breeds like Siberian Huskies with heterochromia irides are predisposed, but presentation can vary.
Observation:
- A 7-year-old Siberian Husky presented with unilateral ocular pain, later diagnosed as panuveitis, iris bombé, and secondary glaucoma.
- Associated clinical signs included bilateral decreased tear production, facial and truncal poliosis, and vitiligo.
- Histopathology confirmed UDS with lichenoid interface dermatitis and pigmentary incontinence.
Findings:
- Treatment with corticosteroids, azathioprine, and a carbonic anhydrase inhibitor was initiated.
- Despite treatment, secondary glaucoma was refractory, leading to enucleation of the affected eye.
- The contralateral eye remained unaffected, and partial pigmentary recovery was observed in the skin.
Implications:
- This case underscores that UDS should be considered in dogs with unilateral ocular signs, irrespective of heterochromia.
- Asymmetric presentation highlights the importance of thorough ophthalmic and dermatologic evaluation in predisposed breeds.
- Prompt diagnosis and management are essential for preserving vision and managing skin manifestations.