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Related Experiment Videos

More TORC for the gluconeogenic engine.

Alan Cheng1, Alan R Saltiel

  • 1Department of Internal Medicine, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, 48109, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|February 16, 2006
PubMed
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Transducer of Regulated CREB activity 2 (TORC2) acts as a molecular switch for hepatic gluconeogenesis. Hormones and cellular energy levels regulate TORC2

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Metabolism

Background:

  • Hepatic gluconeogenesis is crucial for maintaining blood glucose levels.
  • Glucagon stimulates hepatic gluconeogenesis, while insulin and adiponectin inhibit it.
  • TORC2 (Transducer of Regulated CREB activity 2) is a transcriptional regulator involved in metabolic pathways.

Purpose of the Study:

  • To identify key regulators of hepatic gluconeogenesis.
  • To elucidate the role of TORC2 in the gluconeogenic program.
  • To understand how hormones and cellular energy status influence TORC2 activity.

Main Methods:

  • The study involved identifying and characterizing the role of TORC2 in regulating gluconeogenic gene expression.
  • Investigated the effects of insulin, glucagon, and AMPK on TORC2 phosphorylation.

Related Experiment Videos

  • Examined the impact of these signaling pathways on TORC2's nuclear/cytoplasmic localization and transactivation function.

    • Main Results:

    • TORC2 was identified as a pivotal component of the gluconeogenic program.
    • Insulin and AMPK increase TORC2 phosphorylation, whereas glucagon suppresses it.
    • TORC2 phosphorylation status dictates its subcellular localization and ability to regulate gluconeogenic genes.

    Conclusions:

    • TORC2 functions as a molecular switch in hepatic gluconeogenesis.
    • TORC2 integrates signals from hormones (glucagon, insulin) and cellular energy status (AMPK).
    • TORC2's activity is critical for controlling glucose homeostasis.