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Published on: May 29, 2017
Synthesis of [18F]flunarizine
1Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor 48109.
Abstract:
Flunarizine, a calcium channel antagonist of the piperazine class, has been labeled with the positron-emitter 18F.4-[18F]Fluoro-4-fluorobenzhydryl chloride was prepared in three steps from no-carrier-added [18F]fluoride ion, and used in the alkylation of N-cinnamylpiperazine to give [18F]flunarizine in 13% radiochemical yield (from [18F]fluoride).

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