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Related Experiment Videos

UK acquired hepatitis E--An emerging problem?

G J Sadler1, G F G Mells, N H Shah

  • 1Department of Gastroenterology, The Heart of England Foundation Trust, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, United Kingdom.

Journal of Medical Virology
|February 17, 2006
PubMed
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Hepatitis E (HEV) infection acquired in the UK is rare but increasing. This study reports eight UK-acquired cases, suggesting HEV should be considered in acute hepatitis patients regardless of travel history.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis E virus (HEV) is typically associated with travel to endemic areas.
  • UK-acquired HEV infections are considered unusual, with only five cases previously reported.
  • A cluster of eight HEV cases acquired within the UK was observed.

Purpose of the Study:

  • To report an increase in locally acquired Hepatitis E infections in the UK.
  • To highlight the potential for HEV acquisition without international travel.
  • To emphasize the need to consider HEV in differential diagnoses of acute hepatitis.

Main Methods:

  • Retrospective case series analysis.
  • Clinical data review of eight patients presenting with acute hepatitis.

Related Experiment Videos

  • Epidemiological investigation of UK-acquired HEV cases.

    • Main Results:

    • Eight cases of Hepatitis E acquired in the UK were identified over a 5-month period in 2005.
    • This series represents a significant increase in reported UK-acquired HEV infections.
    • The cases presented to an inner-city hospital in Birmingham, UK.

    Conclusions:

    • Hepatitis E should be considered in the diagnosis of acute hepatitis, even in patients without a travel history to endemic regions.
    • The findings suggest a potential rise in the incidence of UK-acquired HEV.
    • Further surveillance and research into local HEV transmission routes are warranted.