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Updated: Aug 11, 2026
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Prodromes and predictors of migraine attack
Paolo Rossi1, Anna Ambrosini, M Gabriella Buzzi
1Headache Clinic, INI Grottaferrata, Rome, Italy. paolo.rossi90@tin.it
Functional Neurology
|February 18, 2006
Summary
Migraine premonitory symptoms, often overlooked, are diverse changes preceding attacks. Research suggests these symptoms may serve as markers for migraine subgroups and treatment responses.
Area of Science:
- Neurology
- Neuroscience
- Headache Medicine
Background:
- Premonitory symptoms of migraine are diverse cognitive, psychic, and physical changes occurring hours to days before an attack.
- These symptoms have been historically neglected in migraine research, often considered secondary phenomena rather than core features.
- Recent advances in understanding migraine pathogenesis highlight the need to re-evaluate these premonitory symptoms.
Purpose of the Study:
- To provide a comprehensive critical review of premonitory symptoms in migraine.
- To examine the current state of research, including epidemiological, clinical, genetic, and pathophysiological studies.
- To explore the potential of premonitory symptoms as phenotypic markers for migraine classification and treatment.
Main Methods:
- Critical literature review of epidemiological, clinical, genetic, and pathophysiological studies on migraine premonitory symptoms.
- Analysis of existing data regarding the heterogeneity and clinical significance of these symptoms.
- Synthesis of recent findings on migraine pathogenesis to contextualize premonitory symptom research.
Main Results:
- Studies on premonitory symptoms often lack scientific rigor, yielding conflicting results.
- Epidemiological and clinical investigations show significant heterogeneity in reported symptoms.
- Early-stage genetic and pathophysiological research indicates potential underlying mechanisms.
Conclusions:
- Premonitory symptoms are a significant, yet understudied, aspect of migraine.
- Evidence suggests premonitory symptoms could be valuable phenotypic markers for identifying migraine subgroups.
- Further rigorous research is essential to elucidate the clinical, pathophysiological, and therapeutic implications of premonitory symptoms.
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