Related Experiment Videos
Effect of (+/-)-DOI on neuromuscular transmission: a microelectrode study
B J Bhattacharyya1, M D Sokoll, J P Long
1Department of Anesthesia, College of Medicine, University of Iowa, Iowa City 52242.
European Journal of Pharmacology
|March 19, 1991
Abstract:
DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) significantly depressed end plate current (EPC) amplitude. It decreased quantum content, increased the extent of neurally evoked EPC rundown during the train, produced a nonlinear current-voltage relationship, shortened time constant of decay, and depressed iontophoretically evoked EPC. The depressant response of DOI on EPC amplitude was antagonized by 5-HT1-like receptor antagonists, but was resistant to 5-HT2 and 5-HT3 receptor antagonists. This suggests that inhibitory 5-HT receptors roughly correspond to 5-HT1-like receptors.