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[Functional food and bioavailability in the target organ skin]

M Darwin1, S Schanzer, A Teichmann

  • 1Center of Experimental and Applied Cutaneous Physiology (CCP), Klinik für Dermatologie, Venerologie und Allergologie, Charité, Universitätsmedizin Berlin.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|February 18, 2006
PubMed

Insights

Environmental factors generate free radicals, damaging skin cells. Consuming antioxidants like carotenoids protects skin, reducing aging and wrinkling.

Area of Science:

  • Dermatology
  • Biochemistry
  • Biophysics

Background:

  • Reactive free radicals from environmental factors (sun radiation, toxins) damage skin cells, leading to aging, immune suppression, and cancer.
  • Antioxidant substances, like dietary carotenoids, are crucial for protecting against free radical damage.
  • Human bodies cannot produce all necessary antioxidants, necessitating dietary intake.

Purpose of the Study:

  • To investigate the kinetics of antioxidant accumulation in the skin using non-invasive optical methods.
  • To assess the impact of dietary carotenoids on skin antioxidant concentrations.
  • To explore the relationship between skin antioxidant levels and visible signs of aging, such as wrinkling.

Main Methods:

  • Utilized optical, non-invasive resonance Raman spectroscopy for real-time detection of antioxidants.
  • Monitored the qualitative and quantitative online kinetics of carotenoids in the skin.
  • Correlated skin antioxidant concentrations with environmental factors and physiological conditions.

Main Results:

  • Demonstrated that dietary carotenoid intake leads to their accumulation in the skin.
  • Observed that stress, illness, and UV radiation decrease skin antioxidant concentrations.
  • Found a significant association between higher skin antioxidant levels and reduced skin wrinkling.

Conclusions:

  • Dietary antioxidants, particularly carotenoids, can be effectively accumulated in the skin.
  • Maintaining adequate skin antioxidant levels is vital for mitigating UV-induced damage and skin aging.
  • Resonance Raman spectroscopy is a valuable tool for monitoring skin health and antioxidant status.

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