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Updated: Jul 14, 2026
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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Mapping normal and cancer cell signalling networks: towards single-cell proteomics
Jonathan M Irish1, Nikesh Kotecha, Garry P Nolan
1Department of Medicine, Oncology Division, Stanford University, Stanford, California 94305, USA.
Nature Reviews. Cancer
|February 24, 2006
Summary
Single-cell proteomics analyzes cell signaling in individual cancer cells to understand tumor progression. This approach identifies therapeutic targets and biomarkers for improved cancer diagnosis and patient prognosis.
Area of Science:
- Cancer Biology
- Proteomics
- Cell Signaling
Background:
- Oncogenesis and tumor progression are driven by altered cell signaling pathways.
- Understanding these signaling alterations at a single-cell level is crucial for effective cancer treatment.
Approach:
- Flow cytometry enables the analysis of signaling events within individual cancer cells.
- This data facilitates the construction of cell-specific signaling network maps.
Key Points:
- Single-cell proteomics links specific signaling profiles to clinical outcomes.
- Identifies signaling pathways active in therapy-resistant cancer cells.
- Potential for discovering novel biomarkers for cancer diagnosis and prognosis.
Conclusions:
- Single-cell proteomics offers a powerful tool for dissecting cancer cell signaling.
- Enables the identification of predictive biomarkers and therapeutic targets for personalized cancer medicine.
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