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Updated: Aug 11, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
Central nervous system and other effects
1Amylin Pharmaceuticals, Inc., San Diego, California, USA.
Abstract:
Amylin enhanced the uptake of certain amino acids, crossed the blood-brain barrier, and increased body temperature. The physiological significance of these responses is currently unclear. An effect of peripherally injected amylin to enhance weakly trained memory fitted with similar effects of other gastrointestinal peptide hormones. Centrally administered amylin reduced locomotor and exploratory behavior. Amylin administered alone was analgesic when administered peripherally, via a non-opiate pathway. When administered in combination with opiates, there was an opiate-sparing synergy.
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