Related Experiment Video
Updated: Aug 11, 2026

06:49
Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
Published on: April 7, 2023
[Pregnancies occurring during oral contraception: lessons from the GRECO study]
P Barjot1, O Graesslin, D Cohen
1Service de Gynécologie-Obstétrique, Polyclinique du Parc, 20, avenue Guynemer, 14052 Caen cedex 04, France. barjot.p@cegetel.net
Gynecologie, Obstetrique & Fertilite
|February 24, 2006
Summary
Oral contraceptive failure, often due to missed pills, is common. The GRECO study found missed pills were the primary cause, leading most women to terminate their pregnancy.
Area of Science:
- Reproductive Health
- Contraception Research
- Pregnancy Outcomes
Context:
- The GRECO study prospectively collected data on pregnancies in women using oral contraceptives.
- Analysis included 551 women in France in 2002, with pregnancies ≤12 weeks gestation.
- Participants were recruited from gynecology, obstetrics, family planning, and termination of pregnancy services.
Purpose:
- To investigate the causes of oral contraceptive failure.
- To identify the types of oral contraceptives used and their failure rates.
- To understand women's decisions regarding pregnancy following contraceptive failure.
Summary:
- Estroprogestative combinations were used by 88% of women experiencing contraceptive failure.
- Missed pills were the most frequent cause of oral contraceptive failure (60.8%), followed by vomiting and diarrhea.
- Levonorgestrel was the most common progestogen (59.0%), and 81.5% of women opted for pregnancy termination.
Impact:
- Highlights the significant impact of missed pills on oral contraceptive effectiveness.
- Informs healthcare providers about common reasons for contraceptive failure and patient choices.
- Provides data for improving contraceptive counseling and patient adherence strategies.
Related Concept Videos
Birth Control Methods
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
Oogenesis
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Ovarian Cycle
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Gonadal and Placental Hormones
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
Intrauterine Drug Delivery Systems
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...