Related Experiment Video
Updated: Aug 10, 2026

07:59
Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis
Published on: May 18, 2016
Diffuse unilateral subacute neuroretinitis in Africa
F Rasquin1, M-P Waterschoot, H Termote
1Department of Ophthamology, Erasme University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium. frasquin@ulb.ac.be
Ocular Immunology and Inflammation
|March 2, 2006
Summary
Diffuse unilateral subacute neuroretinitis (DUSN) was identified in a Senegalese child, caused by a small nematode. This finding expands the known geographic distribution of DUSN to Africa.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Parasitology
Background:
- Diffuse unilateral subacute neuroretinitis (DUSN) is an inflammatory condition affecting the optic nerve and retina.
- DUSN is typically associated with specific nematode species endemic to certain regions, including the Americas.
Observation:
- A case of DUSN is presented in a 12-year-old girl from Senegal, Africa.
- The causative worm was localized and measured approximately 600 micrometers in length using fundus camera software.
Findings:
- The identified nematode length is consistent with smaller species previously linked to DUSN in the Americas.
- This case represents the first documented instance of DUSN caused by a small nematode in Africa.
Implications:
- The findings suggest that DUSN may occur in African populations, broadening its known endemic range.
- This case highlights the importance of considering DUSN in the differential diagnosis of neuro-ocular inflammatory conditions in Africa.
- Further research is needed to understand the epidemiology and specific nematode species involved in DUSN in Africa.
Related Concept Videos
Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

