Related Experiment Video
Updated: Aug 11, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
[Menstrual function in adolescent girls in Tbilisi]
Abstract:
700 adolescent girls aged 10-17 were examined in the schools of Tbilisi (2004-2005). The average age of menarche was ascertained to 12.4 y, which does not differ from the corresponding data obtained in 1984 (12.5 y). Premature puberty and menarche was detected in one patient (0.25%), delayed puberty and menarche in 0.75%. The frequency of menstrual rhythm disorders was equal to 38.3%. Authentic increase of frequency of menstrual disorders in I phase of puberty rather than in II phase (49.4%, 20.7%, p<0.001) was detected. Oligomenorrhea was most frequent disorder of menstrual cycle (32.9%). Dysfunctional uterine bleeding was observed in 1.25% of adolescents, algomenorrhea in 18.5%. In cases of combination of menstrual cycle disturbances with clinical symptoms of androgenization, it is possible to consider presence of endocrine-reproductive disorders. High frequency of menstrual disorders, possible occurrence of endocrine and reproductive disorders and low rate of attendance for medical help (2.4%), indicates at importance of their early revealing, for timely treatment and avoiding complications.
Related Concept Videos
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Menses Phase
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
The Menstrual Cycle
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a uterine...
Signs of Puberty
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Menopause