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Updated: Aug 11, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Prolonged cholestasis associated with short-term use of celecoxib
Patrick Chamouard1, Paul Walter, René Baumann
1Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Hôpital de Hautepierre. Patrick.Chamouard@chru-strasbourg.fr
Abstract:
Drug-induced liver injury due to celecoxib, a first generation Cox-2 inhibitor, has been rarely reported. We describe one case of severe and prolonged cholestasis after treatment with celecoxib for 12 days in a young woman with no evidence of other causes of liver disease or allergy. Jaundice lasted for 3 months, pruritus and abnormal liver biochemistry persisted for 18 months after stopping the drug. Liver biopsy specimens showed a cholestatic pattern of liver injury with only minimal mononuclear infiltrate in the portal tracts. This case report supports the notion that celecoxib may cause bland, long term cholestasis.
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