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Published on: March 11, 2016
[How to improve estimation of renal function in the elderly]
Marc Froissart1, Jérôme Rossert
1Université Paris-Descartes, Hôpital européen Georges Pompidou, Inserm U652, 75908 Paris. marc.froissart@egp.aphp.fr
La Revue Du Praticien
|March 8, 2006
Summary
Serum creatinine alone is insufficient for estimating kidney function (GFR). Use formulas like MDRD, especially in the elderly, to accurately calculate estimated GFR for optimal kidney health assessment.
Area of Science:
- Nephrology
- Biochemistry
Context:
- Glomerular filtration rate (GFR) defines kidney function.
- Serum creatinine is a common biomarker, but requires formulaic adjustment for accurate GFR estimation.
- Age-related decline in GFR is a known physiological change.
Purpose:
- To highlight the limitations of using serum creatinine alone for GFR estimation.
- To recommend appropriate formulas for calculating estimated GFR in different adult populations.
- To emphasize the importance of maintaining a minimum GFR for non-kidney disease patients.
Summary:
- Estimated GFR (eGFR) calculation is crucial for assessing kidney function.
- The MDRD formula is recommended over Cockcroft-Gault for eGFR estimation in the elderly due to underestimation issues with the latter.
- A GFR of 60 mL/min/1.73 m2 or higher is considered normal for individuals without kidney disease, irrespective of age.
Impact:
- Improved accuracy in diagnosing and monitoring kidney disease.
- Better clinical decision-making regarding medication dosages and treatment plans.
- Enhanced understanding of age-related changes in renal function.
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