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Oxidative stress, inflammation and early cardiovascular damage in children with chronic renal failure

Aydin Ece1, Fuat Gürkan, Mehmet Kervancioğlu

  • 1Department of Pediatrics, School of Medicine, Dicle University, Diyarbakir, Turkey. draydinece@hotmail.com

Pediatric Nephrology (Berlin, Germany)
|March 8, 2006
PubMed

Insights

Children with chronic renal failure (CRF) exhibit heightened inflammation and oxidant stress, leading to early cardiovascular damage. These factors, including increased malondialdehyde and decreased glutathione, are linked to adverse cardiac changes in pediatric CRF patients.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Research
  • Biochemistry

Background:

  • The interplay between inflammation, oxidative stress, and cardiovascular damage in pediatric chronic renal failure (CRF) remains understudied.
  • Early identification of cardiovascular abnormalities in children with CRF is crucial for timely intervention.

Purpose of the Study:

  • To investigate markers of oxidative stress, inflammation, and early cardiovascular abnormalities in children with CRF.
  • To compare these markers between children with CRF and healthy controls.

Main Methods:

  • Measured erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities, blood glutathione (GSH), and serum malondialdehyde (MDA) levels.
  • Assessed C-reactive protein (CRP) and proinflammatory cytokines (IL-6, TNF-alpha).
  • Evaluated left ventricular masses (LVM) and intima media thicknesses (IMT) in 29 children with CRF and 25 healthy controls.

Main Results:

  • CRF children showed significantly elevated IL-6, TNF-alpha, CRP, and MDA levels, alongside decreased SOD, CAT, and GSH compared to controls.
  • No significant differences in oxidative stress or inflammation markers were observed between non-dialysis and peritoneal dialysis subgroups.
  • Increased LVM and IMT values were significantly higher in children with CRF.

Conclusions:

  • Children with CRF experience increased oxidative stress and inflammation, correlating with early cardiovascular damage.
  • These findings highlight the need for further research with larger cohorts to confirm the observed associations in pediatric CRF.

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